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Wednesday, January 13 • 1:00pm - 1:30pm
Clinical molecular modeling of COVID-19: The decoding of the viral disease with its many faces

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In the light of the COVID 19 pandemic, a comprehensive understanding of COVID 19 and the underlying core molecular mechanisms which control and determine the individual host response is urgently warranted.

To this end, an evidence-based, holistic, precision-medicine approach is required. Molecular Health established an integrated disease-modeling processes — augmented by state-of-the-art data capture, curation, and analysis — to map the totality of fundamental mechanisms involved in COVID 19. Using our Dataome platform, we built a comprehensive COVID 19 disease model that links key molecular players of COVID 19 pathophysiology to disease symptoms, severe manifestations and outcome, or severity-associated risk factors. Our model revealed that the multitude of seemingly disparate clinical phenotypes can largely be linked to the pleiotropic activity of a few core molecular players and mechanisms involved in the host response, thereby offering an in toto approach to decoding the disease. Within six weeks, we generated a current, inclusive atlas of COVID 19 pathogenesis, with potentially significant implications on the development of diagnostic and therapeutic strategies. This project demonstrates the utility of our Dataome platform in decoding complex diseases.



Speakers
avatar for Stephan Brock, Ph.D.

Stephan Brock, Ph.D.

Chief Technology Officer and Co-Founder, Molecular Health
Dr. Brock has worked in several leading positions in the bioinformatics  industry focusing on data integration, text-mining, and content management supporting the pharmaceutical R&D value chain.  As head of development and CEO of Metalife AG, Dr. Brock led a team of 70 analysts... Read More →


Wednesday January 13, 2021 1:00pm - 1:30pm EST